Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site - Nature Communications
www.nature.com
Antibodies targeting the HIV-1 fusion peptide rarely achieve more than 60% neutralization breadth. Here, the authors develop an anti-FP antibody enhancing its potency to 80% and structurally resolve the expanded FP-binding site that allows the antibody to target diverse viral variants.
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The original was posted on /r/science by /u/Biointron on 2023-12-02 02:59:54.

Original Title: Study reveals critical antibody features for ~80% enhanced neutralization breadth and 10-fold potency against the HIV-1 fusion peptide. These findings can help accelerate the development of broad vaccines and therapeutics against HIV-1.