The emergence of Sox and POU transcription factors predates the origins of animal stem cells - Nature Communications
www.nature.com
The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals and show that unicellular SOX can replace SOX2 to induce pluripotency, whilst unicellular POU differs from OCT4.
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The original was posted on /r/science by /u/chrisdh79 on 2024-11-19 15:06:45+00:00.

Original Title: 422-million-year-old ancient animal cell helps scientists create a mouse | Creating functional mouse stem cells capable of developing into a living mouse using genetic material from choanoflagellates, single-celled organisms that predate animals.