Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect - Nature Communications
www.nature.com
The neural mechanisms underlying the antidepressant effects of nitrous oxide remain poorly understood. This study reveals that specific activation of layer V pyramidal neurons in the cingulate cortex rescues stress-associated hypoactivity states and is driven by inhibition of calcium-sensitive potassium channels rather than NMDA-receptor antagonism.
This is an automated archive made by the Lemmit Bot.

The original was posted on /r/science by /u/chrisdh79 on 2025-04-05 02:18:04+00:00.

Original Title: A 180-year-old drug may be the fastest depression treatment ever discovered on mice | A new study shows that nitrous oxide may provide fast relief for those struggling with depression when traditional treatments fail.