Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect - Nature Communications
www.nature.com
The neural mechanisms underlying the antidepressant effects of nitrous oxide remain poorly understood. This study reveals that specific activation of layer V pyramidal neurons in the cingulate cortex rescues stress-associated hypoactivity states and is driven by inhibition of calcium-sensitive potassium channels rather than NMDA-receptor antagonism.
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The original was posted on /r/tech by /u/chrisdh79 on 2025-04-04 11:14:12+00:00.

Original Title: A 180-year-old drug may be the fastest depression treatment ever discovered | A new study shows that nitrous oxide may provide fast relief for those struggling with depression when traditional treatments fail.