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The original was posted on /r/biology by /u/ww-stl on 2025-09-13 10:15:03+00:00.

In Klinefelter syndrome, one X chromosome seems to be dormant, while the Y chromosome is always expressed.

Why aren’t there cases both X chromosomes are expressed and the Y chromosome is dormant? in other words, why don’t individuals with Klinefelter syndrome develop into XXY females? what’s the mechanism behind this?