Tiny sugars in the brain disrupt emotional circuits, fueling depression
www.eurekalert.org
A research team led by C. Justin LEE and LEE Boyoung at the Institute for Basic Science (IBS) has identified a new molecular pathway in the brain that directly links abnormal sugar modifications on proteins to depressive behaviors. Specifically, chronic stress disrupts sugar chains (O-glycans) attached to proteins in the prefrontal cortex, thereby triggering depression. The findings, published in Science Advances, open new possibilities for targeted therapies for treatment-resistant depression.
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The original was posted on /r/science by /u/FunnyGamer97 on 2025-10-04 14:02:34+00:00.

Original Title: Tiny sugars in the brain disrupt emotional circuits, fueling depression, study on mice finds: IBS researchers identify molecular pathway in the mice’s brain that directly links abnormal sugar modifications on proteins to depressive behaviors